Advancing Care for People with High Blood Pressure

A clinical research study for adults with high blood pressure and cardiovascular risk, exploring a potential new treatment to help manage hypertension.

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Eligibility

Are you

18 years or older with high blood pressure and cardiovascular disease (CVD); OR,
55 years or older with high blood pressure and at risk of developing CVD
Taking at least 2 medications for high blood pressure, including a diuretic (water pill)

SCREENING PERIOD

During this period, there will be several health assessments to
help understand if the ZENITH study is a good fit for you.

1-2 visits

TREATMENT PERIOD

During this period, you will visit the study site to receive the study
medication (zilebesiran or placebo).
Throughout the study you will continue taking your current
blood pressure medications.

up to 14 visits

END OF STUDY VISIT

Your health will be checked after your last injection.

1 visit

About the study medication

Zilebesiran

Zilebesiran is an investigational medication that belongs to a new class of medicines called RNA interference (RNAi) therapeutics. It is designed to target and reduce the production of a protein called angiotensinogen (AGT) in the liver.

AGT plays a key role in controlling blood pressure through the renin–angiotensin–aldosterone system (RAAS). By lowering AGT levels, zilebesiran may help reduce high blood pressure and potentially lower the risk of future cardiovascular events such as heart attack or stroke in people with hypertension.

Unlike traditional blood pressure tablets that are taken daily, zilebesiran is given by injection and is being studied for long-lasting effects, potentially requiring dosing only a few times per year.

If you qualify, you will receive

Study medication or placebo administered at no cost
Health monitoring through blood pressure checks, ECGs, and lab tests
Compensation for travel and other study related costs
Full support at every step by our expert healthcare team

Participating in a clinical study is completely voluntary. You can chooseto leave the study at any time.

To register your interest in participating in this trial ,

We offer individuals the unique opportunity to contribute to the advancement of medical science and the development of innovative treatments. Volunteering for clinical research trials can be a rewarding and impactful way to make a difference in healthcare. Here’s why you should consider participating:

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Registered Company Name: PROMED INNOVATIONS
Registered Company Number: 14926187

Member of the society for clinical research sites

Our business hours

Mon – Fri 9:00 am – 5:00 pm
Sat 10:00 am – 3:00pm
Sun Closed